Cart
sales@molnova.com
Home - Products - Angiogenesis - VEGFR - Tyrosine kinase-IN-1

Tyrosine kinase-IN-1

CAS No. 705946-27-6

Tyrosine kinase-IN-1( —— )

Catalog No. M20206 CAS No. 705946-27-6

Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR Flt-1 FGFR1 and PDGFRα with IC50s of 4nM 20nM 4nM 2 nM respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 65 In Stock
10MG 110 In Stock
25MG 222 In Stock
50MG 332 In Stock
100MG 494 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Tyrosine kinase-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR Flt-1 FGFR1 and PDGFRα with IC50s of 4nM 20nM 4nM 2 nM respectively).
  • Description
    Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR Flt-1 FGFR1 and PDGFRα with IC50s of 4nM 20nM 4nM 2 nM respectively）.
  • In Vitro
    Tyrosine kinase-IN-1 is from reference (compound 8K).
  • In Vivo
    Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(0–∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    VEGFR
  • Recptor
    KDR|Flt-1|FGFR1|PDGFRα|PDGFRα
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    705946-27-6
  • Formula Weight
    445.54
  • Molecular Formula
    C26H28FN5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:62.5 mg/mL (160.47 mM)
  • SMILES
    CCN1CCC(CC1)Nc1ccc2NC(=O)\C(=C(/c3ncc(C)[nH]3)c3cccc(F)c3)c2c1
  • Chemical Name
    (Z)-5-((1-ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene)indolin-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Moon K et al. The design synthesis and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4979–4985
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Fargesin

    Fargesin as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats.

  • SU5204

    SU5204, an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and HER2).

  • CL-387785

    CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR(IC50： 370+/-120 pM);is able to overcome resistance caused by the T790M mutation on a functional level.

Sign In Join Free